Back to results
US 8,252,914 B2Granted
Chimeric NK receptor and methods for treating cancer
AssigneeTrustees of Dartmouth College
InventorsTong Zhang, Charles L. Sentman
Life of this patent
Estimating the term…
Abstract
The present invention relates to chimeric immune receptor molecules for reducing or eliminating tumors. The chimeric receptors are composed a C-type lectin-like natural killer cell receptor, or a protein associated therewith, fused to an immune signaling receptor containing an immunoreceptor tyrosine-based activation motif. Methods for using the chimeric receptors are further provided.
Claims5
A nucleic acid construct for expressing a chimeric polypeptide receptor to reduce or eliminate a tumor comprising:
- a first nucleic acid sequence encoding a promoter operably linked to
- a second nucleic acid sequence encoding a chimeric polypeptide receptor comprising DAP10 fused to an immune signaling receptor containing an immunoreceptor tyrosine-based activation motif of SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.