Actriib-Fc polynucleotides, polypeptides, and compositions
AssigneeAcceleron Pharma Inc.
InventorsJohn Knopf, Jasbir Seehra
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Abstract
In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of a tissue, such as bone, cartilage, muscle, fat, and/or neuron. The present invention also provides methods of screening compounds that modulate activity of an ActRII protein and/or an ActRII ligand. The compositions and methods provided herein are useful in treating diseases associated with abnormal activity of an ActRII protein and/or an ActRII ligand.
Claims5
An isolated immunoglobulin Fc-fusion protein expressed in a cell from a nucleic acid sequence encoding a polypeptide comprising the amino acid sequence of SEQ ID NO:15, wherein the amino acid corresponding to position 64 is arginine.
An isolated polypeptide comprising the amino acid sequence of SEQ ID NO:15, wherein the amino acid corresponding to position 64 of SEQ ID NO:15 is arginine.
Dependencies are inferred from the claim text.