Back to results
US 8,242,177 B2Granted
Derivatives of 4-(2-amino-1-hydroxyethyl)phenol as agonists of the β2 adrenergic receptor
AssigneeAlmirall, S.A.
InventorsCarlos Puig Duran, Maria Isabel Crespo Crespo, Julio Cesar Castro Palomino Laria, Silvia Gual Roig, Eloisa Navarro Romero
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to 4-(2-amino-1-hydroxyethyl)phenol derivatives of formula (I) as well as pharmaceutical compositions comprising them, and their use in therapy as agonists of the BETA2 adrenergic receptor.
Claims19
A compound of formula (I):
- wherein:
- R1 is chosen from —CH2OH and —NHC(O)H;
- R2 is a hydrogen atom;
- R3 is chosen from a hydrogen atom, halogen atoms, —SO—R5, —SO2—R5, —NH—CO—NH2, CO—NH2, C1-4alkyl, C1-4alkoxy and —SO2NR5R6;
- R4 is chosen from a hydrogen atom, halogen atoms, and C1-4 alkyl groups;
- R5 is chosen from C1-4 alkyl groups and C3-8 cycloalkyl groups;
- R6 is independently chosen from a hydrogen atom and C1-4 alkyl groups;
- n, p and q are each independently 0, 1, 2, 3 or 4;
- m and s are each independently 0, 1, 2 or 3;
- and
- r is 0, 1 or 2
- with the provisos that:
- at least one of m and r is not 0
- the sum n+m+p+q+r+s is 7, 8, 9, 10, 11, 12 or 13
- the sum q+r+s is 2, 3, 4, 5 or 6
- or a pharmaceutically-acceptable salt or stereoisomer thereof.
13 more elements
Dependencies are inferred from the claim text.