Use of cis-epoxyeicosatrienoic acids and inhibitors of soluble epoxide hydrolase to reduce cardiomyopathy
AssigneeThe Regents of the University of California
InventorsNipavan Chiamvimonvat, Bruce D. Hammock
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Abstract
The invention provides methods for inhibiting cardiomyopathy and for inhibiting cardiac arrhythmia, by administering to an individual in need thereof a cis-epoxyeicosantrienoic acid, an inhibitor of soluble epoxide hydrolase (sEH), or both. In some embodiments, the method comprises administering to the individual a nucleic acid encoding an inhibitor of sEH. Cardiomyopathies treatable by the methods of the invention include cardiac hypertrophy and dilated cardiomyopathy.
Claims22
A method of inhibiting cardiomyopathy or cardiac arrhythmia in an subject in need thereof, said method comprising administering to said subject an effective amount of an inhibitor of soluble epoxide hydrolase (“sEH”), wherein the inhibitor of sEH has a urea, carbamate, or amide pharmacophore, wherein said subject does not have hypertension, or is not being treated for hypertension with an inhibitor of sEH, thereby inhibiting cardiomyopathy or cardiac arrhythmia in said subject.
Dependencies are inferred from the claim text.