Flavanoids and isoflavanoids for the prevention and treatment of cardiovascular diseases

A compound of Formula VII:

• wherein:
• R1, R2, R3, R5, R6, R3, R9, and R10 are each independently selected from alkoxy, aryloxy, alkyl, alkenyl, alkynyl, amide, amino, aryl, arylalkyl, carbamate, carboxy, cyano, cycloalkyl, ester, ether, formyl, halogen, haloalkyl, heteroaryl, heterocyclyl, hydrogen, hydroxyl, ketone, nitro, phosphate, sulfide, sulfinyl, sulfonyl, sulfonic acid, sulfonamide and thioketone;
• R7 is selected from aryloxy, alkyl, alkenyl, alkynyl, amide, aryl, arylalkyl, carbamate, carboxy, cyano, cycloalkyl, ester, ether, formyl, halogen, haloalkyl, heteroaryl, heterocyclyl, hydroxyl, ketone, nitro, phosphate, sulfide, sulfinyl, sulfonyl, sulfonic acid, sulfonamide and thioketone, or
• two adjacent substituents selected from R1, R2, R3, R5, R6, R7, R8, R9, and R10 are connected in a 5 or 6-membered ring to form a bicyclic aryl or bicyclic heteroaryl;
• and pharmaceutically acceptable salts thereof.

A compound selected from

• 2-(5-Methoxy-pyridin-2-yl)-chromen-4-one;
• 2-(5-Hydroxy-pyridin-2-yl)-chromen-4-one;
• 2-(6-Hydroxy-pyridin-3-yl)-chromen-4-one;
• 5,7-Dimethoxy-2-(4′-hydroxy-phenyl)-quinolin-4-one;
• 5,7-Dihydroxy-2-(4-hydroxy-phenyl)-quinolin-4-one;
• 2-(4-Hydroxy-phenyl)-pyrano[3,2-b]pyridin-4-one;
• 2-(4-Methoxyphenyl)-4H-pyrano[2,3-b]pyridine-4-one;
• 2-(4-Hydroxyphenyl)-4H-pyrano[2,3-b]pyridin-4-one;
• 2-(4-(2-Hydroxyethoxy)phenyl)-4H-pyrano[2,3-b]pyridine-4-one;
• 2-(3-Fluoro-4-hydroxyphenyl)pyrano[2,3-b]pyridine-4-one;
• 2-(4-Hydroxy-3-methylphenyl)-4H-pyrano[2,3-b]pyridine-4-one;
• 4-(4-Oxo-4H-pyrano[2,3-b]pyridine-2-yl)benzonitrile;
• 2-(3-Chloro-4-hydroxyphenyl)-4H-pyrano[2,3-b]pyridine-4-one;
• 2-(3-Bromo-4-hydroxyphenyl)-4H-pyrano[2,3-b]pyridin-4-one;
• 2-(4-Hydroxy-3-methoxyphenyl)-4H-pyrano[2,3-b]pyridine-4-one;
• 2-(4-Hyd roxy-phenyl)-pyrano[2,3-c]pyridin-4-one;
• 2-(4-hydroxy-phenyl)-pyrano[3,2-c]pyridin-4-one;
• 3-(4-Hydroxyphenyl)-2H-isoquinolin-1-one;
• 3-(3-Fluoro-4-hydroxyphenyl)-5-methoxyisoquinolin-1(2H)-one;
• 2-Fluoro-4-(5-methoxy-1-(methylamino)-isoquinolin-3-yl)phenol;
• 6-Naphthalen-2-yl-pyridin-3-ol;
• 4-Isoquinolin-3-yl-phenol;
• 4-(1,6-Naphthyridin-7-yl)phenol;
• 2-(4-Hydroxy-phenyl)-[1,4]naphthoquinone;
• 2-(4-Hydroxyphenyl)benzo[e][1,3]oxazin-4-one;
• 6-Naphthalen-2-yl-pyridin-3-ol;
• 2-(4-Ethoxycarbonyloxy-phenyl)-4-oxo-4H-quinoline-1-carboxylic acid ethyl ester;
• 4-(4-oxo-4H-pyrano[2,3-b]pyridine-2-yl)phenyl acetate;
• 4-(Isoquinolin-3-yl)phenyl 2-amino-5-guanidinopentanoate;
• 4-(1-Oxo-1,2-dihydroisoquinolin-3-yl)phenyl 2-amino-5-guanidinopentanoate;
• 5,7-Difluoro-2-(4-hydroxy-phenyl)-chromen-4-one;
• 2-(3,5-Difluoro-4-hydroxyphenyl)chromen-4-one;
• 2-(4-Hydroxy-3,5-dimethylphenyl)chromen-4-one;
• 2-(4-Methoxy-phenyl)-thiochromen-4-one;
• 2-(4-Hydroxy-phenyl)-thiochromen-4-one;
• 2-(4-Hydroxyphenyl)-3-methyl-4H-chromen-4-one;
• 4-(6-Bromo-4-oxo-4H-chromen-2-yl)-2-fluorophenyl acetate;
• 1-(2-Nitro-4-methoxy-phenyl)-chromen-4-one;
• 2-(4-Hydroxy-2-nitrophenyl)chromen-4-one;
• 2-(2-Amino-4-methoxy-phenyl)-chromen-4-one;
• 2-(2-Amino-4-hydroxy-phenyl)-chromen-4-one;
• N-[5-Hydroxy-2-(4-oxo-4H-chromen-2-yl)-phenyl]acetamide;
• 6-Hydroxy-2-(4-hydroxymethylphenyl)chromen-4-one;
• 2-(2-Fluoro-4-hydroxyphenyl)chromen-4-one;
• 2-(4-Hydroxyphenyl)-8-nitro-4H-chromen-4-one;
• 2-(4-Hydroxyphenyl)-8-methoxy-4H-chromen-4-one;
• 2-(4-Hydroxyphenyl)-5,7-dimethoxy-4H-chromen-4-one;
• 2-(3-Bromo-4-hydroxyphenyl)-4H-chromen-4-one;
• 2-(4-Hydroxyphenyl)-4-oxo-4H-chromene-6-carbonitrile;
• 2-(4-Methoxy-phenyl)-chromen-4-one;
• 2-(3-Fluoro-4-hydroxyphenyl)chromen-4-one;
• 2-(4-Hydroxyphenyl)-4-oxo-4H-chromene-6-sulfonic acid;
• 6-Hydroxymethyl-2-(4-hydroxyphenyl)chromen-4-one;
• 6-((Dimethylamino)methyl)-2-(4-hydroxyphenyl)-4H-chromen-4-one;
• 8-Hydroxy-2-(4-hydroxy-phenyl)-chromen-4-one;
• 2-(4-Hydroxy-phenyl)-chromen-4-one;
• 7-Hydroxy-2-(4-hydroxy-phenyl)-chromen-4-one;
• 5-Hydroxy-2-(4-hydroxy-phenyl)-chromen-4-one;
• 5,7-Dihydroxy-2-(4-hydroxy-phenyl)-chromen-4-one;
• 5,7-Dihydroxy-2-phenyl-chromen-4-one;
• 5-Hydroxy-2-phenyl-chromen-4-one;
• 2-(4-Acetoxy-phenyl)-thiochromen-4-one;
• 2-(4-Acetoxy-phenyl)-1,1-dioxo-1H-1λ6-thiochromen-4-one;
• 2-(4-Hydroxy-phenyl)-1,1-dioxo-1H-1λ6-thiochromen-4-one;
• 2-(2-(4-Hydroxyphenyl)-4-oxo-4H-chromen-3-yl)acetonitrile;
• 3-(Hydroxymethyl)-2-(4-hydroxyphenyl)-4H-chromen-4-one;
• 2-(4-Hydroxyphenyl)-3-(methoxymethyl)-4H-chromen-4-one;
• 4-Naphthalen-2-yl-phenol;
• 3-(4-Hydroxyphenyl)-naphthalene-1-ol;
• 4-(Benzo[b][1,4]dioxin-2-yl)phenyl acetate;
• 4-(Benzo[b][1,4]dioxin-2-yl)phenol;
• 4-(4H-Chromen-2-yl)-phenol;
• Nicotinic acid 4-(4-oxo-4H-chromen-2-yl)-phenyl ester;
• Acetic acid 4-(4-oxo-4H-chromen-2-yl)-phenyl ester;
• 2-Amino-5-guanidino-pentanoic acid 4-(4-oxo-4H-chromen-2-yl)phenyl ester;
• and
• 2-(4-(Nicotinoyloxy)phenyl)-4-oxo-4H-chromene-5,7-diyl dinicotinate,
• and pharmaceutically acceptable salts thereof.