Articles including natural biodegradable polysaccharides and uses thereof
AssigneeSurModics, Inc.
InventorsStephen J. Chudzik, Dale G. Swan, Michael J. Burkstrand
Life of this patent
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Abstract
Medical articles having a body member including natural biodegradable polysaccharides are described. The body member is formed from a plurality of natural biodegradable polysaccharides having pendent coupling groups. The body member can also include a bioactive agent which can be released to provide a therapeutic effect to a patient.
Claims25
A medical implant comprising a biodegradable body member comprising a matrix of crosslinked polymers, wherein the matrix is formed from a composition comprising polymers having a molecular weight of 500,000 Da or less and comprising
- repeating glucopyranose units comprising hydroxyl groups present on 2, 3, and 6 position carbons, wherein the glucopyranose units are joined by α-1,4 linkages,
- pendent polymerizable groups, and
- an ester group present between the pendent polymerizable group and the glucopyranose unit, wherein the ester group is formed from esterification of a hydroxyl group selected from the hydroxyl groups present on the 2, 3, and 6 position carbons of the glucopyranose unit which comprises the formula:
- where X represents the 6 position carbon, and Y represents the 2 or 3 position carbon of the glucopyranose unit.
An ocular implant comprising a biodegradable body member comprising a matrix comprising crosslinked polymers, wherein the matrix is formed from a composition comprising polymers having a molecular weight of 500,000 Da or less and comprising
- repeating glucopyranose units comprising hydroxyl groups present on 2, 3, and 6 position carbons, wherein the glucopyranose units are joined by α-1,4 linkages
- pendent polymerizable groups, and
- an ester group present between the pendent polymerizable group and the glucopyranose unit, wherein the ester group is formed from esterification of a hydroxyl group selected from the hydroxyl groups present on the 2, 3, and 6 position carbons of the glucopyranose unit which comprises the formula:
- where X represents the 6 position carbon, and Y represents the 2 or 3 position carbon of the glucopyranose unit, and wherein the ocular implant further comprises a bioactive agent comprising a polypeptide.
A medical implant comprising a biodegradable body member comprising a matrix of polymers, wherein the matrix is formed from a composition comprising polymers having a molecular weight of 500,000 Da or less and comprising repeating glucopyranose units comprising hydroxyl groups present on 2, 3, and 6 position carbons, wherein the glucopyranose units are joined by α-1,4 linkages, and pendent polymerizable groups, and an ester group present between the pendent polymerizable group and the glucopyranose unit which comprises the formula:
- where X represents the 6 position carbon, and Y represents the 2 or 3 position carbon of the glucopyranose unit, and the polymers are at a concentration in the range of 200 mg[mL to 2000 mg/mL in the composition.
Dependencies are inferred from the claim text.