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AssigneeEM Biotecnologia S.A.
InventorsChristophe Francois Aime Roca, José Manuel Bernardo Sousa, Marta Isabel Heitor Cerejo, Alexandra Maria Barros Dos Santos, Cátia Santana Reverendo Rodrigues, Ricardo Filipe Antunes Pinheiro, Patricia Ramalhete Mendes da Silva Calado, Sukalyan Chatterjee, Helena Margarida Moreira de Oliveira Vieira
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The present invention relates to a cell comprising an Endoplasmic Reticulum (ER) stress element operably linked to a reporter element and an exogenous gene encoding a protein that induces ER stress. Methods of screening using the modified cell, constructs used in the modified cell, the candidate agents identified by the screen and uses thereof are also part of the invention.
An isolated cell comprising an Endoplasmic Reticulum (ER) stress sensor element operably linked to a reporter element and comprising an exogenous gene encoding a protein that induces ER stress.
Dependencies are inferred from the claim text.