Methods and compositions for treatment of hematologic cancers
AssigneeViralytics Limited
InventorsGough Geoffrey Au, Darren Raymond Shafren
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Abstract
The present invention relates to oncolytic Picornaviruses and methods and compositions for treating subjects having hematologic cancers. These include methods and compositions for treatment of myeloma, using disclosed Picornavirus such as Coxsackievirus, in methods of direct or indirect administration to subjects and ex vivo purging of malignant cells within auto grafts prior to transplantation.
Claims9
A method for treating and/or preventing hematologic cancer in a subject, the method comprising administering a therapeutically effective amount of a Picornavirus or a modified form thereof such that at least some cells of the cancer undergo viral oncolysis, wherein said administration comprises ex vivo purging by said Picornavirus, or modified form thereof, of malignant cells within auto grafts prior to autologous stem cell transplantation, or comprises ex vivo purging of malignant cells within auto grafts prior to transplantation, wherein the auto grafts comprise hematopoietic stem cells.
Dependencies are inferred from the claim text.