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US 8,232,448 B2Granted
Transgenic mouse with a homozygous mutation in the CMAH gene
AssigneeThe Regents of the University of California
InventorsAjit Varki, Anna Maria Hedlund, Dzung Nguyen
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Abstract
This application is in the field of sialic acid chemistry, metabolism, antigenicity, and the production of transgenic non-human mammals with altered sialic acid production. More particularly, this application relates to N-glycolylneuraminic acid (Neu5Gc) being an immunogen in humans, and the production of Neu5Gc-free mammalian products for laboratory and human use.
Claims3
A viable and fertile transgenic mouse that
- a) comprises a genome having a homozygous mutation of the cytidine-5′-monophosphate N-acetyl neuraminic acid hydrolase (CMAH) gene,
- b) lacks expression of enzymatically active CMAH protein encoded by said CMAH gene, and
- c) lacks N-glycolylneuraminic acid (Neu5Gc) in one or more body fluid or tissue.
Dependencies are inferred from the claim text.