Tetra calcium phosphate based organophosphorus compositions and methods
AssigneeHowmedia Osteonics Corp.
InventorsVenkat R. Garigapati, Brian J. Hess, Jon Ahola
Life of this patent
Estimating the term…
Abstract
Compositions and methods of their use to adhere a variety of materials together are disclosed herein. The compositions include at least tetra calcium phosphate, an effective amount of a compound that is structurally similar to phosphoserine, and can be mixed with an aqueous solution. The compositions provide adhesive and cohesive strength in both wet and dry environments and exhibit significant bond strength upon curing.
Claims75
An adhesive composition comprising;
- a mixture of;
- tetra calcium phosphate, wherein the tetra calcium phosphate is present in an amount from about 10% to about 90% by weight based on the combined weight of the tetra calcium phosphate and a compound;
- and
- the compound of the formula;
- where A is O, CH2, or S;
- R is H, NH2, NHCO(CH2)tCH3 where t is 0 to 2, NH(CH2)xCH3 where x is 0 to 3, NR1R2 where R1 is (CH2)yCH3 and R2 is (CH2)yCH3 where y is 0 to 2, (CH2)zCH3 where z is 0 to 3, where m is 0 to 1, and where n is 0 to 3 and wherein the compound is present in an amount from about 10% to about 90% by weight based on the combined weight of the tetra calcium phosphate and the compound,
- and an aqueous medium;
- wherein the composition has an adhesive strength upon curing of greater than 250 kPa.
an adhesive composition comprising:
- tetra calcium phosphate, wherein the tetra calcium phosphate is present in an amount from about 10% to about 90% by weight based on the combined weight of the tetra calcium phosphate and a compound;
- and
- the compound of the formula
- where A is O, CH2, or S;
- R is H, NH2, NHCO(CH2)tCH3 where t is 0 to 2, NH(CH2)xCH3 where x is 0 to 3, NR1R2 where R1 is (CH2)yCH3 and R2 is (CH2)yCH3 where y is 0 to 2, (CH2)zCH3 where z is 0 to 3, where m is 0 to 1, and where n is 0 to 3 and wherein the compound is present in an amount from about 10% to about 90% by weight based on the combined weight of the tetra calcium phosphate and the compound;
- wherein the composition when mixed with an aqueous medium has an adhesive strength upon curing of greater than 250 kPa.
A kit for forming an adhesive calcium phosphate bone restorative product comprising:
- a composition comprising an effective amount of tetra calcium phosphate and a compound of the formula
- where A is O, CH2, or S;
- R is H, NH2, NHCO(CH2)tCH3 where t is 0 to 2, NH(CH2)xCH3 where x is 0 to 3, NR1R2 where R1 is (CH2)yCH3 and R2 is (CH2)yCH3 where y is 0 to 2, (CH2)zCH3 where z is 0 to 3, where m is 0 to 1, and where n is 0 to 3 and wherein the compound is present in an amount from about 10% to about 90% by weight based on the combined weight of the tetra calcium phosphate and the compound contained within a first container, and wherein the tetra calcium phosphate is present in an amount from about 10% to about 90% by weight based on the combined weight of the tetra calcium phosphate and a compound;
- and
- an aqueous medium contained within a second container;
- wherein the composition has an adhesive strength upon curing greater than 250 kPa.
an adhesive composition that comprises an effective amount of tetra calcium phosphate, wherein the tetra calcium phosphate is present in an amount from about 10% to about 90% by weight based on the combined weight of the tetra calcium phosphate and a compound, and a compound of the formula
- where A is O, CH2, or S;
- R is H, NH2, NHCO(CH2)tCH3 where t is 0 to 2, NH(CH2)xCH3 where x is 0 to 3, NR1R2 where R1 is (CH2)yCH3 and R2 is (CH2)yCH3 where y is 0 to 2, (CH2)zCH3 where z is 0 to 3, where m is 0 to 1, and where n is 0 to 3 and an aqueous medium wherein the composition has a tacky state for up to 12 minutes after the composition is mixed with the aqueous medium, has a separation strength in the range of about 10 kPa to about 250 kPa during the tacky state, has a putty state for up to 15 minutes after the composition is mixed with the aqueous medium, and an adhesive strength upon curing of greater than 250 kPa.
Dependencies are inferred from the claim text.