Pharmaceutical compositions containing 1-methyl-D-tryptophan
AssigneeGeorgia Health Sciences University
InventorsDavid Munn, Andrew Mellor
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Abstract
The present invention discloses pharmaceutical compositions containing 1-methyl-D-tryptophan and its utility to enhance rejection of tumor or virus-infected cells or to delay the progression of tumor growth. The present invention shows that pharmaceutical compositions containing 1-methyl-D-tryptophan enhance the efficacy of alternative antitumor or antiviral treatments such as chemotherapy, vaccination or cytokine therapy.
Claims16
A pharmaceutical composition for the treatment of cancer or an infection, the composition consisting of a therapeutically effective amount of 1-methyl-D-tryptophan and a pharmaceutically acceptable carrier, wherein the pharmaceutical composition is formulated for oral delivery in a tablet or capsule.
A pharmaceutical composition for the treatment of cancer or an infection, the composition consisting of (a):
- 1-methyl-D-tryptophan;
- (b) at least one therapeutic agent selected from the group consisting of a chemotherapeutic agent, an antimicrobial agent, an antiviral agent, wherein said therapeutic agent does not include 1-methyl-L-tryptophan and (c) a pharmaceutically acceptable carrier.
A pharmaceutical composition for the treatment of cancer or an infection, the composition comprising a therapeutically effective amount of 1-methyl-D-tryptophan, but not 1-methyl-L-tryptophan, in combination with a pharmaceutically acceptable carrier, wherein the pharmaceutical composition is formulated for oral delivery as a tablet or capsule.
A pharmaceutical composition comprising a therapeutically effective amount of 1-methyl-D-tryptophan, wherein said 1-methyl-D-tryptophan is not contained within a racemate, wherein the composition is formulated for oral delivery in a tablet or capsule.
Dependencies are inferred from the claim text.