Uses of DPP-IV inhibitors
AssigneeBoehringer Ingelheim International GmbH
InventorsKlaus Dugi, Frank Himmelsbach, Michael Mark
Life of this patent
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Abstract
The specification describes the use of selected DPP IV inhibitors for the treatment of physiological functional disorders and for reducing the risk of the occurrence of such functional disorders in at-risk patient groups. In addition, the use of the above-mentioned DPP IV inhibitors in conjunction with other active substances is described, by means of which improved treatment outcomes can be achieved. These applications may be used to prepare corresponding medicaments.
Claims47
A method of reducing the risk of a macrovascular complication in the treatment of patients who have been diagnosed with manifest type 2 diabetes comprising the steps of preparing an oral medicament comprising 1-[(4-methyl -quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(R)-amino-piperidin-1-yl) -xanthine or one of the salts thereof,
- and administering said oral medicament to said patient,
- wherein the oral medicament is a tablet and the amount of said 1-[(4-methyl -quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(R)-amino-piperidin-1-yl) -xanthine administered to said patient is 0.5 mg, 1 mg, 2.5 mg, 5 mg, or 10 mg, and
- wherein the macrovascular complication is myocardial infarction, acute coronary syndrome, unstable angina pectoris, stable angina pectoris, haemorrhagic or ischaemic stroke, peripheral arterial occlusive disease, cardiomyopathy, left heart insufficiency, right heart insufficiency, global heart failure, heart rhythm disorders, or vascular restenosis.
A method of treating a patient who has been diagnosed with manifest type 2 diabetes comprising administering to the patient an oral medicament in the form of a tablet comprising 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(R)-amino-piperidin-1-yl)-xanthine or one of the salts thereof,
- wherein the amount of said 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(R)-amino-piperidin-1-yl)-xanthine administered to said patient is 0.5 mg, 1 mg, 2.5 mg, 5 mg, or 10 mg, and
- wherein the risk of a macrovascular complication is reduced by using the medicament, and
- wherein the macrovascular complication is myocardial infarction, acute coronary syndrome, unstable angina pectoris, stable angina pectoris, haemorrhagic or ischaemic stroke, peripheral arterial occlusive disease, cardiomyopathy, left heart insufficiency, right heart insufficiency, global heart failure, heart rhythm disorders, or vascular restenosis.
A method of reducing the risk of a macrovascular complication in the treatment of patients who have been diagnosed with manifest type 2 diabetes comprising administering to a patient in need thereof an oral medicament in the form of a tablet comprising 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl -7-(2-butyn-1-yl) 8-(3-(R)-amino-piperidin-1-yl)-xanthine in an amount of 2.5 mg or 5 mg,
- wherein the macrovascular complication is myocardial infarction, acute coronary syndrome, unstable angina pectoris, stable angina pectoris, haemorrhagic or ischaemic stroke, peripheral arterial occlusive disease, cardiomyopathy, left heart insufficiency, right heart insufficiency, global heart failure, heart rhythm disorders, or vascular restenosis.
A method of reducing the risk of a macrovascular complication in the treatment of patients who have been diagnosed with manifest type 2 diabetes comprising administering to a patient in need thereof an oral medicament in the form of a tablet comprising 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl) -8-(3-(R)-amino-piperidin-1-yl)-xanthine in an amount of 5 mg,
- wherein the macrovascular complication is myocardial infarction, acute coronary syndrome, unstable angina pectoris, stable angina pectoris, haemorrhagic or ischaemic stroke, peripheral arterial occlusive disease, cardiomyopathy, left heart insufficiency, right heart insufficiency, global heart failure, heart rhythm disorders, or vascular restenosis.
A method of reducing the risk of a macrovascular complication in the treatment of patients who have been diagnosed with manifest type 2 diabetes comprising administering to a patient in need thereof an oral medicament in the form of a tablet comprising 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl) -8-(3-(R)-amino-piperidin-1-yl)-xanthine,
- wherein the macrovascular complication is myocardial infarction, acute coronary syndrome, unstable angina pectoris, stable angina pectoris, haemorrhagic or ischaemic stroke, peripheral arterial occlusive disease, cardiomyopathy, left heart insufficiency, right heart insufficiency, global heart failure, heart rhythm disorders, or vascular restenosis, and
- wherein the total daily dose of 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(R)-amino-piperidin-1-yl)-xanthine administered is 5 mg.
Dependencies are inferred from the claim text.