Back to results
US 8,232,244 B2Granted
Compositions and methods to prevent cancer with cupredoxins
AssigneeThe Board of Trustees of the University of Illinois
InventorsTapas Das Gupta, Ananda Chakrabarty, Craig Beattie, Tohru Yamada
Life of this patent
Estimating the term…
Abstract
The present invention discloses methods and materials for delivering a cargo compound into a cancer cell. Delivery of the cargo compound is accomplished by the use of protein transduction domains derived from cupredoxins. The cargo compound may be a nucleic acid and specifically a DNA, RNA or anti-sense. The invention further discloses methods for treating cancer and diagnosing cancer.
Claims46
An isolated peptide that is a variant, derivative or structural equivalent of a cupredoxin;
- and that can inhibit the development of premalignant lesions in mammalian tissue;
- wherein the isolated peptide is a truncation of the cupredoxin;
- and
- wherein the peptide comprises a sequence selected from the group consisting of Pseudomonas aeruginosa azurin residues 50-77, Pseudomonas aeruginosa azurin residues 50-67, Pseudomonas aeruginosa azurin residues 36-88, and SEQ ID NOs:
- 20-24.
2 more elements
Dependencies are inferred from the claim text.