Optical microlabels: shapes and reflectors
OwnerRichard C. Willson, Raul Ruchhoedftinventors
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Abstract
Labels and methods of producing labels for use in clinical, analytical and pharmaceutical development assays are provided. Labels may comprise shape-encoded particles which may be coupled to ligands such as DNA, RNA and antibodies, where different shapes are used to identify which ligand(s) are present. Labels may also comprise reflectors, including retroreflectors and retroreflectors susceptible to analyte-dependent assembly for efficient homogeneous assays.
Claims8
An apparatus comprising a substrate, a top layer disposed on a top surface of the substrate and recessed regions having at least three mutually-perpendicular, adjacent faces, where at least two faces of each of the regions comprise a portion of the top layer and one face comprises a portion of the substrate, where at least two faces are coated with a reflective material so that they comprise mirrored surfaces, at least one face is functionalized with a biological recognition moiety, and a largest dimension of the faces is less than 2 mm.
Dependencies are inferred from the claim text.