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US 8,231,930 B2Granted
Self-aggregating protein compositions and use as sealants
AssigneeMaquet Cardiovascular LLC
InventorsDan Castro, Al Kuehn, Moon Hae Sunwoo
Life of this patent
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Abstract
An implantable member for use in the body is provided herein. This implantable member includes a porous biocompatible substrate; the substrate having at least one surface sealed fluid-tight with self-aggregating protein particles of substantially the same diameter range. The self-aggregated protein particles are formed from a deposited aqueous slurry of the protein particles.
Claims17
A process for making an implantable member for use in the body comprising the steps of:
- (a) providing a porous biocompatible substrate having at least one surface;
- (b) providing a non-crosslinked sealant composition, said sealant composition comprising self-aggregating purified protein particles of substantially uniform particle size, said protein particles being obtained by cryogenically milling said protein in a purified form suitable for implantation;
- (c) applying said sealant composition to at least a portion of said surface of the substrate;
- and
- (d) allowing said sealant composition to dry so as to provide a fluid-tight seal of said portion;
- wherein said sealant composition has not been exposed to a cross-linking agent.
3 more elements
Dependencies are inferred from the claim text.