Compositions and methods using microspheres and non-ionic contrast agents
AssigneeBiosphere Medical, Inc.
InventorPhilippe Reb
Life of this patent
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Abstract
The present invention relates to compositions and methods for treating diseases and disorders including cancer and various other angiogenic-dependent diseases, vascular malfunctions, arteriovenous malformations (AVM), hemorrhagic processes and treatment of pain, in particular tumor-related pain by drug delivery and/or therapeutic embolization using microspheres. More particularly the invention relates to microspheres containing non-ionic contrast agents, to compositions comprising these microspheres, as well as methods for preparing and using such compositions for embolization therapy. The invention further relates to compositions and methods using detectable microspheres for targeted drug delivery, irrespective of whether embolization is also needed.
Claims25
A method for managing or treating a hepatocellular disease in a patient, comprising administering to the patient a substantially spherical microsphere comprising:
- (a) a non-ionic contrast agent, wherein the contrast agent is metrizamide, iodixanol, iohexyl, ioversol, iopromide, iobitridol, iomeprol, iopentol, ioxilan, iotrolan, or mixtures thereof, (b) doxorubicin, wherein microsphere comprising a biocompatible polymeric material comprising a sodium acrylate and vinyl alcohol copolymer, wherein the microsphere is swellable in a pharmaceutically acceptable solution and has a diameter of from about 10 μm to about 2000 μm before swelling.
Dependencies are inferred from the claim text.