Catalyst and reaction process
AssigneeJapan Science and Technology Agency
InventorsShu Kobayashi, Magno Agostinho, Uwe Schneider, Miyuki Yamaguchi
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Abstract
Disclosed is a technology for enabling an efficient asymmetric Michael addition reaction which does not require a large amount of a malonic ester, while having a short reaction time. Specifically disclosed is a catalyst which is composed of MX2 (wherein M is Be, Mg, Ca, Sr, Ba or Ra and X is an arbitrary group) and a compound represented by general formula [I]. [In the formula, R7, R8, R9 and R10 each represents a substituted cyclic group or an unsubstituted cyclic group.]
Claims12
A reaction method, comprising reacting a compound represented by formula [II] with a compound represented by formula [III] in the presence of a catalyst configured using MX2 and a compound represented by formula [I], to form a compound of formula [IV]:
- wherein:
- R1, R2, R3 and R4 individually represent a H or a hydrocarbon;
- W1, W2 and W3 individually represent an electron-withdrawing group selected from the group consisting of an ester group, a carboxyl group, a carbonyl group, a nitrile group and a nitro group;
- M is Sr;
- X is an alkoxide group, an amide group, or a hexamethyldisilazide group;
- and
- R7, R8, R9, and R10 each represents a substituted cyclic group or a unsubstituted cyclic group and wherein optionally R9 and R10 form a ring.
Dependencies are inferred from the claim text.