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US 8,221,495 B2Granted
Integration of therapeutic agent into a bioerodible medical device
AssigneeAbbott Laboratories
InventorsSanjay Shrivastava, John Toner, Sandra Burke, Keith Cromack, Peter Tarcha, Donald Verlee
Life of this patent
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Abstract
A medical device which is at least partially bio-erodible and which exhibits controlled elution of therapeutic agent.
Claims35
An implantable medical device comprising:
- a body comprising a plurality of fused particles of bioerodible powder material, the particles of bioerodible powder material including particles of bioerodible polymer;
- and
- at least one therapeutic agent incorporated throughout the bioerodible powder material, wherein the body includes small and large pores on a tubular surface of the body, the large pores being larger than the small pores, the small pores collectively located on a first portion of a circumference of the tubular surface, the large pores collectively located on a second portion of the circumference of the tubular surface, the first portion circumferentially offset from the second portion, and the at least one therapeutic agent is disposed in at least some of the small and large pores.
An implantable medical device comprising:
- a body comprising a plurality of fused bioerodible particles including particles of bioerodible polymer;
- and
- at least one therapeutic agent incorporated throughout the bioerodible particles before the bioerodible particles are fused.
An implantable medical device comprising:
- an expandable stent body comprising a bioerodible powder and a therapeutic agent, the bioerodible powder and the therapeutic agent pressed together, the bioerodible powder forming a microstructure in which the therapeutic agent is integrated, the bioerodible powder including particles of bioerodible polymer.
Dependencies are inferred from the claim text.