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US 8,221,411 B2Granted
Systems and methods for cardiac tissue electroporation ablation
AssigneeMedtronic, Inc.
InventorsDavid Francischelli, Mark Stewart, Jinback Hong, Vladimir Nikolski, Cushing Hamlen, Daniel Cheek, Matthew Bonner
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Abstract
Cardiac electroporation ablation systems and methods in which pulsed, high voltage energy is delivered to induce electroporation of cells of cardiac tissue followed by cell rupturing. In some embodiments, the delivered energy is biphasic, having a cycle time of not more than 500 microseconds.
Claims4
A cardiac tissue electroporation ablation system comprising:
- a delivery instrument maintaining at least one electroporation electrode;
- and
- an electrical pulse generator electrically connected to the at least one electroporation electrode;
- wherein the pulse generator is programmed to deliver pulsed, high voltage biphasic energy to the electroporation electrode sufficient to induce IEP ablation of cardiac tissue cells, including an output voltage in the range of 200-700 volts, a pulse width in the range of 50-200 microseconds, a pulse interval in the range of 100-400 microseconds, and as a series of pulse trains over a range of 2-6 seconds with a train interval in the range of 250-1,000 milliseconds.
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Dependencies are inferred from the claim text.