Treatment for obesity
AssigneeUnigene Laboratories Inc.
InventorsNozer M. Mehta, Amy Sturmer, William Stern, James P. Gilligan
Life of this patent
Estimating the term…
Abstract
The present invention provides peptides and pharmaceutical compositions thereof for appetite suppression and weight control. Preferred peptides are calcitonin analogs, preferably with specific amino acid changes to make the peptide more amylin-like.
Claims20
A 33 amino acid peptide, wherein the peptide is not eel or salmon calcitonin or human amylin, and wherein the thirty-one amino acids making up positions 2-33 of the peptide are identical to the thirty-one amino acids making up positions 1-32 of SEQ ID NO:
- 1.
A peptide whose amino acid sequence is at least 93 percent identical to SEQ ID NO:
- 1, wherein the peptide is not eel or salmon calcitonin or human amylin, wherein positions 2-30 of the peptide are identical to positions 2-30 of SEQ ID NO:
- 1, wherein position 26 of the peptide is Asp, wherein position 27 of the peptide is Val, wherein position 29 of the peptide is Ala, wherein position 30 of the peptide is Asn, and wherein position 1 of the peptide is cysteine that has been modified to reduce its positive charge.
Dependencies are inferred from the claim text.