Compositions, methods and kits relating to anti-platelet autoantibodies and inhibitors thereof
AssigneeThe Trustees of the University of Pennsylvania
InventorDonald L. Siegel
Life of this patent
Estimating the term…
Abstract
The present invention relates to novel methods of identifying and producing an anti-platelet autoantibody. More preferably, the invention relates to identification and production of a human monoclonal anti-platelet autoantibody. Moreover, the invention relates to methods for treating or alleviating a disease, disorder or condition mediated by an anti-platelet autoantibody specifically binding with a platelet, or a component thereof, such as, but not limited to, idiopathic thrombocytopenic purpura, among others. Preferably, the antibody is an unglycosylated H44L4 Fab.
Claims2
A method for inhibiting blood clotting in vivo, said method comprising administering to a human patient an effective amount of an antibody that inhibits platelet function in vivo, thereby inhibiting blood clotting in vivo, wherein said antibody is an unglycosylated H44L4 Fab [SEQ ID NO:64 (H44) and SEQ ID NO:70 (L4)].
A method of contacting an antibody with a glycoprotein IIb/IIIa on a platelet in vivo, comprising administering an effective amount of an antibody to a human patient, wherein said antibody is an unglycosylated H44L4 Fab [SEQ ID NO:64 (H44) and SEQ ID NO:70 (L4)], further wherein when said antibody is bound to said glycoprotein IIb/IIIa on a platelet, platelet function is inhibited.
Dependencies are inferred from the claim text.