US 8,211,656 B2Granted

Biological targeting compositions and methods of using the same

AssigneeThe Invention Science Fund I, LLC

InventorsRoderick A. Hyde, Muriel Y. Ishikawa, Edward K. Y. Jung, William Gates, Alois A. Langer, Eric C. Leuthardt, Royce A. Levien, Clarence T. Tegreene, Thomas A. Weaver, Charles Whitmer, Lowell L. Wood, Jr., Victoria Y. H. Wood

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Abstract

Modified red blood cells are described. In an embodiment, the modified red blood cell includes a target-binding agent. Targeted delivery of imaging agents, drugs, and peptide and protein pharmaceuticals using modified red blood cells are described. Processes for preparing the modified red blood cells, pharmaceutical and diagnostic compositions containing the same and methods of diagnosis and treatment involving the modified red blood cells are described.

Claims24

Dependent claims

A method for detecting a target in a biological sample, comprising:

adding to the biological sample a red blood cell that binds to the target, the red blood cell including one or more fusion molecules, and at least one target-binding agent including a target recognition moiety, wherein the target recognition moiety is configured to recognize one or more target cells, and wherein the one or more fusion molecules are configured to promote fusion of the red blood cell with the one or more target cells;
and detecting the modified red blood cell.

Dependencies are inferred from the claim text.