P53 modulator and cancer target
AssigneeBoard of Regents, The University of Texas System
InventorMichelle Barton
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Abstract
Methods of screening for modulators of TRIM24 (also known as TIF1-ALPHA) expression and/or biological activity are described. In particular, methods of screening of screening for modulators of TRIM24 E3 ligase activity, and specifically an E3 ligase activity directed at p53 as the target polypeptide are also described. Modulators of TRIM24 expression and activity are provided and their use in treatment of cancer, particularly in breast, colon, prostate, renal cancers and in acute lymphoblastic leukaemia. Suitable modulators of TRIM24 expression include siRNA and shRNA and can be used in the treatment of cancer and for targeting cancer stem cells.
Claims7
A method of identifying a modulator of TRIM24 (TIF-1 a) activity comprising:
- (i) exposing a TRIM24 polypeptide, or a cell expressing such a peptide, to a plurality of candidate compounds;
- (ii) determining whether one or more of the candidate compounds modulate the E3 ligase activity of TRIM24 or its binding to p53;
- and
- (iii) providing a compound determined to modulate the E3 ligase activity of TRIM24 or its binding to p53.
Dependencies are inferred from the claim text.