Compounds that stimulate glucose utilization and methods of use
AssigneeThe Governors of the University of Alberta
InventorsGary D. Lopaschuk, John C. Vederas, Jason R. Dyck
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Abstract
The invention provides novel compounds of the Formula (I) that stimulate rates of glucose oxidation in myocardial cells: wherein W, Cyc, p, Y, X, Z, R, R1, R2, R3, R4, I, m and n are as defined for Formula (I) herein. The invention also relates to pharmaceutical compositions comprising compounds capable of stimulation of glucose oxidation, methods for increasing glucose oxidation rates in myocardial cells, and methods of treatment of myocardial ischemia.
Claims4
A method for increasing glucose utilization in a cell, tissue or organ of a warm blooded animal which comprises treating said cell, tissue or organ with a glucose utilization effective amount of a compound selected from the group consisting of
Dependencies are inferred from the claim text.