# US 8,202,853 B2 · Convenience kit for eyelid treatment

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- Number: US 8,202,853 B2
- Document ID: US8202853B2
- Status: Granted
- Kind: B2
- Application number: 12/346,552
- Filed: 2008-12-30
- Published: 2009-05-28
- Granted: 2012-06-19
- Earliest claimed: 2006-11-03
- Assignees: OCuSOFT, Inc.
- Inventors: Nat G Adkins, Jr.
- Web page: https://patentgrep.com/patent/US8202853B2

## CPC

- A61K 8/20: Halogens; Compounds thereof
- A61K 8/345: {containing more than one hydroxy group}
- A61K 8/44: Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K 8/442: {substituted by amido group(s)}
- A61K 8/463: {containing sulfuric acid derivatives, e.g. sodium lauryl sulfate}
- A61K 8/4993: {Derivatives containing from 2 to 10 oxyalkylene groups}
- A61K 8/604: {Alkylpolyglycosides; Derivatives thereof, e.g. esters}
- A61K 8/84: obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K 8/86: Polyethers
- A61K 9/0048: {Eye, e.g. artificial tears}
- A61K 9/10: Dispersions; Emulsions
- A61K 31/047: having two or more hydroxy groups, e.g. sorbitol
- A61K 31/155: Amidines ([IMAGE cpc-sch-A61K-1029.gif]), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
- A61P 31/04: Antibacterial agents
- A61Q 1/14: Preparations for removing make-up
- A61Q 17/005: {Antimicrobial preparations}
- A61Q 19/005: {Preparations for sensitive skin}
- A61Q 19/10: Washing or bathing preparations
- A61K 2800/28: Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
- A61K 2800/52: Stabilizers
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

The present invention offers an eyelid treatment kit used for convenient combination therapy for improving overall eyelid hygiene while also providing for adjunctive eyelid therapy. The eyelid treatment kit comprises low dose doxycycline hyclate tablets, a non-irritating eyelid cleansing composition, an anti-bacterial eyelid preparation and at least one pair of moist heat goggles and/or one pair of moisture chamber goggles. The eyelid treatment kit further comprises instruction sheets containing dosage and administration information on the doxycycline hyclate coupled with information on improving eyelid hygiene. The various embodiments of the eyelid treatment kit of the invention facilitate treatment of dry eyes due to infected eyelids, and proper cleansing of the eyelids to prevent recurring infections.

## Claims

### Claim 1

An eyelid treatment kit, the kit comprising:
a tetracycline antibiotic;
a non-irritating eyelid cleansing composition;
an anti-bacterial eyelid preparation; and
an eyewear apparatus
wherein the tetracycline antibiotic is doxycycline, minocycline, tetracycline, oxytetracycline, chlortetracycline, demeclocycline or pharmaceutical acceptable derivatives thereof, wherein the non-irritating eyelid cleansing composition comprises a surfactant mixture comprising PEG-80 sorbitan laurate, sodium trideceth sulfate, PEG-150 distearate, disodium lauroamphodiacetate, cocamidopropyl hydroxysultaine, sodium laureth-13 carboxylate, sodium chloride, PEG-15 cocopolyamine, quaternium-15 and deionized water; wherein the anti-bacterial eyelid preparation comprises polyhexamethylene biguanide, 1,2-hexanediol, 1,2-octanediol and a pH stabilizing surfactant solution present in an amount effective to control the pH level of the composition between 5.5 and 7.5.

### Claim 2 (depends on 1)

The eyelid treatment kit of claim 1 wherein the tetracycline antibiotic is doxycycline hyclate having a molecular formula of C22H24N2Ox.H2O.

### Claim 3 (depends on 2)

The eyelid treatment kit of claim 2, wherein the doxycycline hyclate is adapted to be administered in the form of one or more tablets.

### Claim 4 (depends on 3)

The eyelid treatment kit of claim 3, wherein each tablet containing from about 15 mg to about 50 mg doxycycline hyclate.

### Claim 5 (depends on 2)

The eyelid treatment kit of claim 2, wherein the doxycycline hyclate is adapted to be administered in the form of a suspension.

### Claim 6 (depends on 1)

The eyelid treatment kit of claim 1, wherein the non-irritating eyelid cleansing composition is in a form chosen from an aqueous emulsion, a suspension, a dispersion, a foam, a cream, a lotion, a solution, a paste, a gel or a spray.

### Claim 7 (depends on 1)

The eyelid treatment kit of claim 1, further comprising a pump dispenser containing the non-irritating eyelid cleansing composition of claim 1.

### Claim 8 (depends on 1)

The eyelid treatment kit of claim 1, further comprising a container comprising a solution of the non-irritating eyelid cleansing composition.

### Claim 9 (depends on 8)

The eyelid treatment kit of claim 8, further comprising one or more applicators for applying the solution.

### Claim 10 (depends on 9)

The eyelid treatment kit of claim 9, wherein the applicator is selected from a group consisting of a swab, a fabric pad or cotton balls.

### Claim 11 (depends on 1)

The eyelid treatment kit of claim 1, wherein the anti-bacterial eyelid preparation is in a form chosen from an aqueous emulsion, a suspension, a dispersion, a foam, a cream, a lotion, a solution, a paste, a gel or a spray.

### Claim 12 (depends on 1)

The eyelid treatment kit of claim 1, further comprising a fabric pad, the fabric pad pre-moistened with the anti-bacterial eyelid preparation, wherein the fabric pad is applied to the eyelids to be treated.

### Claim 13 (depends on 12)

The eyelid treatment kit of claim 12, wherein the fabric pad comprises a heating element enclosed within the pad.

### Claim 14 (depends on 1)

The eyelid treatment kit of claim 1, wherein the eyewear apparatus comprises at least one pair of moist heat goggles, the moist heat goggles further comprising means to create heat and increase humidity around the eye to stimulate tear production and reduce the evaporation of natural tears.

### Claim 15

An eyelid treatment kit, the kit comprising:
a container comprising one or more doxycycline hyclate tablets;
a non-irritating eyelid cleansing composition, the non-irritating eyelid cleansing composition comprising a surfactant mixture comprising PEG-80 sorbitan laurate, sodium trideceth sulfate, PEG-150 distearate, disodium lauroamphodiacetate, cocamidopropyl hydroxysultaine, sodium laureth-13 carboxylate, sodium chloride, PEG-15 cocopolyamine, quaternium-15 and deionized water;
an anti-bacterial eyelid preparation for treating eyelids, the anti-bacterial eyelid preparation comprising polyhexamethylene biguanide, 1,2-hexanediol, 1,2-octanediol and a pH stabilizing surfactant solution present in an amount effective to control the pH level of the composition between 5.5 and 7.5;
at least one pair of moist heat goggles; and
one or more instruction sheets containing doxycycline hyclate tablet dosage and administration information coupled with information on improving eyelid hygiene.

### Claim 16 (depends on 15)

The eyelid treatment kit of claim 15, wherein the anti-bacterial eyelid preparation further comprises one or more moisturizers.

### Claim 17 (depends on 16)

The eyelid treatment kit of claim 16, wherein the moisturizer is selected from a group consisting of methyl gluceth-20, sorbital, glycerine, glycols, propylene glycol, carboxylates, amino acids, glucoside derivatives, urea, lactates, and derivatives of pantothenic acid.

### Claim 18 (depends on 15)

The eyelid treatment kit of claim 15, further comprising a pump dispenser containing the anti-bacterial eyelid preparation, wherein the anti-bacterial eyelid preparation is capable of forming a stable foam when dispersed from the pump dispenser.

### Claim 19 (depends on 15)

The eyelid treatment kit of claim 15, further comprising an applicator, the applicator comprising a fabric pad with a surface area dimensioned to accommodate a therapeutic dose of the anti-bacterial eyelid preparation.

### Claim 20 (depends on 15)

The eyelid treatment kit of claim 15, further comprising at least one pair of moisture chamber goggles, wherein the moist chamber goggles, when worn by a user, is adapted to define a heated chamber around the eyes to open clogged meibomian glands.

### Claim 21

An eyelid treatment kit, the kit comprising:
a light-resistant container comprising one or more low-dose doxycycline hyclate tablets, the tablets containing less than 50 mg doxycycline hyclate;
a pump dispenser containing a non-irritating eyelid cleansing composition, the non-irritating eyelid cleansing composition comprising a surfactant mixture comprising PEG-80 sorbitan laurate, sodium trideceth sulfate, PUG-150 distearate, disodium lauroamphodiacetate, cocamidopropyl hydroxysultaine, sodium laureth-13 carboxylate, sodium chloride, PEG-15 cocopolyamine, quaternium-15 and deionized water;
one or more fabric pads pre-moistened with an anti-bacterial eyelid preparation, the anti-bacterial eyelid preparation comprising polyhexamethylene biguanide, 1,2-hexanediol, 1,2-octanediol and a pH stabilizing surfactant solution present in an amount effective to control the pH level of the composition between 5.5 and 7.5;
a heating element enclosed within each fabric pad;
at least one pair of moist heat goggles and/or one pair of moisture chamber goggles; and
one or more instruction sheets containing doxycycline hyclate tablet dosage and administration information.

### Claim 22 (depends on 21)

The eyelid treatment kit of claim 21, further comprising an impervious wrapper for enclosing the pre-moistened fabric pads.

### Claim 23 (depends on 21)

The eyelid treatment kit of claim 21, wherein the heating element enclosed within the fabric pads is a heat generator, the means for heat generation selected from an exothermic chemical reaction, conductive heat transfer from an internal heating pouch, conductive heat transfer from an enclosed heating pouch, molecular excitation via a microwave energy source, or a combination thereof.