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US 8,202,833 B2Granted
Composition containing biocompatible polymerization accelerator and polymerizable material
AssigneeSurModics, Inc.
InventorsDale G. Swan, Stephen J. Chudzik, Ronald F. Ofstead
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Abstract
The present invention provides method and materials for forming a polymeric matrix having improved biocompatible properties. A polymerization accelerator is provided that includes an N-vinyl group and a biocompatible functional group. The polymerization accelerator is particularly useful for the polymerization of macromers, which can be used to form biocompatible polymeric coatings on the surface of biological materials, such as cells and tissue.
Claims24
A composition comprising:
- (a) a polymerization accelerator comprising a biocompatible functional group, wherein the biocompatible functional group comprises a sulfonate group;
- and
- (b) a polymerizable material, wherein the polymerization accelerator is able to be reacted with the polymerizable material to form a biocompatible matrix and the polymerization accelerator increases the rate that the polymerizable material becomes incorporated into the biocompatible matrix.
A composition comprising:
- (a) a polymerization accelerator comprising a biocompatible functional group selected from the group consisting of phosphonate (PO3−), sulfonate (SO3−), and carboxylate (COO−), a carbonyl group, and an N-vinyl group;
- and
- (b) a polymerizable material, wherein the polymerization accelerator increases the rate that the polymerizable material becomes incorporated into a polymerized product in a polymerization reaction.
A composition comprising:
- (a) a polymerization accelerator comprising:
- i) a biocompatible functional group selected from the group consisting of phosphonate (PO3−), sulfonate (SO3−), and carboxylate (COO−), ii) an N-vinyl group, and iii) a carbonyl group;
- and
- (b) a macromer,
- wherein the polymerization accelerator is able to be reacted with the macromer to form a biocompatible matrix and the polymerization accelerator increases the rate that the macromer becomes incorporated into the biocompatible matrix.
2 more elements
Dependencies are inferred from the claim text.