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US 8,202,690 B2Granted
Cancer marker and therapeutic agent for cancer
AssigneesHisamitsu Pharmaceutical Co., Inc., Chiba-Prefecture
InventorsYasutoshi Tatsumi, Akira Nakagawara
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Abstract
A novel cancer marker is provided. A method for detecting cancer using a level of BMCC1 gene expression as an indication is provided, in which the cancer is selected from the group consisting of prostate cancer, lung cancer, gastric cancer, bladder cancer, and uterine cancer.
Claims2
A method for detecting cancer in a specimen suspected of cancer, comprising:
- measuring a level of BCH motif-containing molecule at the carboxyl terminal region 1 gene expression in the specimen suspected of cancer;
- comparing the level of BCH motif-containing molecule at the carboxyl terminal region 1 gene expression in the specimen suspected of cancer with a level of BCH motif-containing molecule at the carboxyl terminal region 1 gene expression in a normal specimen and a level of BCH motif-containing molecule at the carboxyl terminal region 1 gene expression in a cancer specimen;
- comparing the level of Differential Display Code 3 gene expression in the specimen suspected of cancer with a level of Differential Display Code 3 gene expression in a normal specimen and a level of Differential Display Code 3 gene expression in a cancer specimen;
- and
- determining the specimen suspected of cancer is cancerous when:
- the level of BCH motif-containing molecule at the carboxyl terminal region 1 gene expression in the specimen suspected of cancer is either (i) lower than the level of BCH motif-containing molecule at the carboxyl terminal region 1 gene expression in the normal specimen, (ii) the same level as the level of BCH motif-containing molecule at the carboxyl terminal region 1 gene expression in the cancer specimen, or, both (i) and (ii);
- and
- the level of Differential Display Code 3 gene expression in the specimen suspected of cancer is either (i) higher than the level of Differential Display Code 3 gene expression in the normal specimen, (ii) the same level as the level of Differential Display Code 3 gene expression in the cancer specimen, or, both (i) and (ii);
- wherein the cancer is prostate cancer.
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