Mesocellular oxide foams as hemostatic compositions and methods of use
AssigneeThe Regents of the University of California
InventorsGalen Stucky, Sarah Baker, April Sawvel
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Abstract
The present invention relates to hemostatic compositions comprising a mesocellular oxide foam and, optionally, a biologically active agent such as a procoagulant, as well as devices and methods of use to promote blood clotting.
Claims16
A hemostatic composition comprising a hemostatically effective amount of a sterile, mesocellular oxide foam,
- wherein the mesocellular foam is characterized by an average pore size of from about 10 nm to 100 nm, and wherein the mesocellular foam has an average pore window size of at least 11 nm, and
- wherein the mesocellular foam comprises a bound biologically active agent comprising a clot promoting agent.
A thrombin-loaded mesocellular oxide foam comprising at least 5% by weight thrombin, wherein the mesocellular foam is characterized by an average pore size of from about 10 nm to 100 nm, and wherein the mesocellular foam has an average pore window size of at least 11 nm.
A method of making a hemostatic composition, the method comprising:
- contacting a mesocellular oxide foam characterized by an average pore size of from about 10 nm to 100 nm and an average pore window size of at least 11 nm with a solution containing a biologically active agent, said contacting being for a time sufficient to provide for adsorption or absorption of the biologically active agent to the mesocellular foam;
- wherein a hemostatic composition comprising the mesocellular oxide foam and bound biologically active agent is produced, and
- wherein the biologically active agent comprises a clot promoting agent.
Dependencies are inferred from the claim text.