Abuse resistant opioid drug-ion exchange resin complexes having hybrid coatings

A solid oral dose tablet, powder or granular formulation having modified release characteristics comprising at least one hybrid coated opioid-ion exchange resin complex and pharmaceutically acceptable excipients, said at least one hybrid coated opioid-ion exchange resin complex comprising:

• a pharmaceutically effective amount of an opioid bound to a pharmaceutically acceptable ion exchange resin;
• and
• a cured hybrid modified release coating layer over the opioid-ion exchange resin complex, said hybrid coating comprising:
• a pH-independent, high tensile strength, water insoluble, water-permeable, diffusion barrier coating forming component comprising about 70% to about 90% w/w polyvinylacetate (PVA) and about 3 to about 10% w/w of a plasticizer;
• and
• an enteric coating forming component having pH-dependent solubility in an aqueous system which is non-reactive with said barrier coating forming component, said enteric coating forming component comprising polyvinylacetate phthalate,
• wherein said barrier coating forming component and said enteric coating forming component are present in a weight ratio of about 20:1 to about 3:1.