Method of producing tibolone metabolites by fermentation with Cunninghamella elegans
OwnerAttaur Rahman, Muhammed Iqbal Choudhary +2inventors
InventorsAttaur Rahman, Muhammed Iqbal Choudhary, Syed Adnan Ali Shah, Shamsun Nahar Khan
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Abstract
A method of producing Δ1,4-Tibolone (C21H26O2), 10β-Hydroxy-Δ4-tibolone (C21H28O3). 11α,15β-Dihydroxytibolone (C21H28O4) and 11α,15β-Dihydroxy-Δ5-tibolone (C21H28O4) by contacting tibolone and 3β,6β-Dihydroxytibolone (C21H32O3) by contacting 3β-hydroxytibolone with Cunninghamella elegans (ATCC 10028b) is reported.
Claims3
A microbial method of producing Δ1,4-Tibolone (C21H26O2), 10β-Hydroxy-Δ4-tibolone (C21H28O3), 11α,15β-Dihydroxytibolone (C21H28O4) and 11α,15β-Dihydroxy-Δ5-tibolone (C21H28O4) by growing Cunninghamella elegans (ATCC 10028b) in a nutrient media containing tibolone.
A microbial method of producing 3β,6β-Dihydroxytibolone (C21H32O3) by growing contacting Cunninghamella elegans (ATCC 10028b) in a nutrient media containing 3β-hydroxytibolone.
A microbial method of producing 3α-Hydroxy-Δ5-tibolone, 3α,6β-Dihydroxy-Δ4-tibolone, and 3α,11α-Dihydroxy-Δ4-tibolone by growing Cunninghamella elegans (ATCC 10028b) in a nutrient media containing 3α-Hydroxytibolone.
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