Human milk oligosaccharides to promote growth of beneficial gut bacteria
AssigneeThe Regents of the University of California
InventorsDavid A. Mills, Carlito B. Lebrilla, Riccardo LoCascio, Milady Ninonuevo, J. Bruce German, Samara Freeman
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Abstract
The present invention provides prebiotic and probiotic compositions containing human milk oligosaccharides and methods of use that selectively promote the growth of beneficial gut bacteria.
Claims20
A synthetic prebiotic composition comprising a first, second and third purified oligosaccharide each of which naturally occur in human breast milk, wherein the first oligosaccharide has a mass/charge (m/z) ratio of about 732.3;
- the second oligosaccharide has a mass/charge (m/z) ratio of about 1243.4;
- and the third oligosaccharide has a mass/charge (m/z) ratio of about 1389.5,
- wherein the m/z ratio is measured by matrix-assisted laser desorption/ionization (MALDI), and
- wherein the composition is consumed at a higher rate by Bifidobacterium longum bv. infantis (B. infantis) compared to other Bifidobacterium strains.
A synthetic prebiotic composition comprising at least three purified oligosaccharides that naturally occur in human breast milk, wherein the oligosaccharides have a mass/charge (m/z) ratio selected from the group consisting of about 878.3, about 1097.4, about 1243.4, about 1389.5, about 1462.5, about 1608.6, about 1754.6, about 1827.6, and about 1900.7,
- wherein the m/z ratio is measured by matrix-assisted laser desorption/ionization (MALDI), and
- wherein the composition is consumed at a higher rate by Bifidobacterium longum bv. infantis (B. infantis) compared to other Bifidobacterium strains.
Dependencies are inferred from the claim text.