Ion channel modulators and methods of use

A compound of formula I:

• or a pharmaceutically acceptable salt thereof, wherein
• R′1 and R1 are independently —ZAR4, wherein each ZA is independently a bond or an optionally substituted branched or straight C1-12 aliphatic chain wherein up to three carbon units of ZA are optionally and independently replaced by —C(O)—, —C(S)—, —C(O)NRA—, —C(O)NRANRA—, —C(O)O—, —NRAC(O)O—, —O—, —NRAC(O)NRA—, —NRANRA—, —S—, —SO—, —SO2—, —NRA—, —SO2NRA—, or —NRASO2NRA—;
• R4 is independently RA, halo, —OH, —CN, —NO2, —NH2, or —OCF3;
• RA is independently hydrogen, an optionally substituted aryl, or an optionally substituted heteroaryl;
• or
• R′1 and R1 together with the nitrogen atom to which they are attached form a heterocycloaliphatic that is substituted with two of —ZBR5, wherein each ZB is independently a bond or an optionally substituted branched or straight C1-6 aliphatic chain wherein up to three carbon units of ZB are optionally and independently replaced by —C(O)—, —C(S)—, —C(O)NRB—, —C(O)NRBNRB—, —C(O)O—, —NRBC(O)O—, —O—, —NRBC(O)NRB—, —NRBNRB—, —S—, —SO—, —SO2—, —NRB—, —SO2NRB—, or —NRBSO2NRB—;
• R5 is independently RB, halo, —OH, —CN, —NO2, —NH2, ═O, or —OCF3;
• RB is independently hydrogen, or an optionally substituted heteroaryl;
• R2 is —ZCR6, wherein each ZC is independently a bond or an optionally substituted branched or straight C1-6 aliphatic chain wherein up to two carbon units of ZC are optionally and independently replaced by —C(O)—, —C(S)—, —C(O)NRC—, —C(O)NRCNRC—, —C(O)O—, —NRCC(O)O—, —O—, —NRCC(O)NRC—, —NRCNRC—, —S—, —SO—, —SO2—, —SO2NRC—, or —NRCSO2NRC—;
• R6 is independently RC, halo, —OH, —CN, —NO2, —NH2, or —OCF3;
• RC is independently hydrogen, optionally substituted cycloaliphatic, optionally substituted heterocycloaliphatic, optionally substituted aryl, or optionally substituted heteroaryl;
• R3 is —ZDR7, wherein each ZD is independently a bond or an optionally substituted branched or straight C1-6 aliphatic chain wherein up to two carbon units of ZD are optionally and independently replaced by —C(O)—, —C(S)—, —C(O)NRD—, —C(O)NRDNRD—, —C(O)O—, —NRDC(O)O—, —O—, —NRDC(O)NRD—, —NRDNRD—, —S—, —SO—, —SO2—, —NRD—, —SO2NRD—, or —NRDSO2NRD—;
• R7 is independently RD, halo, —OH, —CN, —NO2, —NH2, or —OCF3;
• and
• RD is independently hydrogen, optionally substituted cycloaliphatic, optionally substituted heterocycloaliphatic, optionally substituted aryl, or optionally substituted heteroaryl.