Optimized FC variants
AssigneeXencor, Inc.
InventorsGregory Alan Lazar, Wei Dang, John R. Desjarlais, Sher Bahadur Karki, Omid Vafa, Robert Hayes, Jost Vielmetter
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Abstract
The present invention relates to optimized Fc variants, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
Claims10
A protein comprising an Fc variant of a parent Fc polypeptide, wherein said Fc variant comprises an amino acid modification in the Fc region of said parent Fc polypeptide at position 243, wherein said protein exhibits altered binding affinity to an Fcγ receptor (FcγR) as compared to a parent polypeptide, wherein numbering is according to the EU index.
A protein comprising an Fc variant of a parent Fc polypeptide, wherein said Fc variant comprises an amino acid modification in the Fc region of said parent Fc polypeptide at position 243, wherein numbering is according to the EU index.
A protein comprising an Fc variant of a parent Fc polypeptide, wherein said Fc variant comprises an amino acid modification in the Fc region of said parent Fc polypeptide selected from the group consisting of 243E, 243H, 243L, 243Q, 243R, 243W and 243Y, wherein numbering is according to the EU index.
An antibody or immunoadhesin, wherein said antibody or immunoadhesin comprises an amino acid modification in the Fc region selected from the group consisting of 243E, 243H, 243L, 243Q, 243R, 243W and 243Y, wherein numbering is according to the EU index.
Dependencies are inferred from the claim text.