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US 8,187,810 B2Granted
Method for diagnosing overactive bladder
AssigneesWellman Wai-Man Cheung, Martin Heath Bluth
InventorsMartin Heath Bluth, Wellman W. Cheung
Life of this patent
Estimating the term…
Abstract
Techniques for diagnosing overactive bladder (OAB) in a patient are provided. For example, a technique for diagnosing overactive bladder in a patient includes the step of obtaining peripheral blood mononuclear cells (PBMC) from the patient to provide a reporter function in the patient.
Claims4
A method of diagnosing overactive bladder (OAB) in a human patient, the method comprising:
- isolating ribonucleic acid (RNA) from peripheral blood mononuclear cells (PBMC) of the patient and from the PBMC of at least one appropriately matched control subject;
- converting the RNA to complementary RNA (cRNA);
- and
- subjecting the cRNA to microarray analysis to determine cRNA levels of at least one gene selected from the group consisting of platelet-derived growth factor (PDGF), microfibrillar-associated protein 3-like (MFAP3L), and tropomyosin 1 (TPM1), wherein a difference in the cRNA levels of said at least one gene between the patient's cRNA and the cRNA of the at least one appropriately matched control subject indicates that the patient be diagnosed with OAB.
1 more element
A method of diagnosing overactive bladder (OAB) in a female human patient, the method comprising:
- isolating ribonucleic acid (RNA) from peripheral blood mononuclear cells (PBMC) of the female patient and from the PBMC of at least one appropriately matched female control subject;
- converting the RNA to complementary RNA (cRNA);
- and
- subjecting the cRNA to microarray analysis to determine cRNA levels of at least one gene selected from the group consisting of progesterone receptor membrane component 1 (PGRMC1), eukaryotic translation initiation factor 2 subunit 3 (EIF2S3), complement component 3a receptor 1 (C3ARI), and myomesin M-protein 2 (MYOM2),
- wherein a difference in the cRNA levels of said at least one gene between the female patient's cRNA and the cRNA of the at least one appropriately matched female control subject indicates that the female patient be diagnosed with OAB.
2 more elements
Dependencies are inferred from the claim text.