Oligonucleotide-containing pharmacological compositions and their use

A composition suitable for administration in a mammal suffering from a pathological disorder or disease comprising at least two modified oligonucleotides,

• wherein a first and a second modified oligonucleotide each comprises about seven to seventy-five nucleotides containing seven or more contiguous ribose groups linked by achiral 5′ to 3′ internucleotide phosphate linkages,
• wherein at least one ribose group of at least one of said modified oligonucleotides has a modified 2′ substituent, wherein the 5′ and 3′ ends of at least one of said modified oligonucleotides are blocked,
• wherein said first modified oligonucleotide is SEQ ID NO:
• 1, wherein said second modified oligonucleotide is SEQ ID NO:
• 16, and
• wherein said first modified oligonucleotide is complementary to a region of a first gene associated with said pathological disorder or disease and said second modified oligonucleotide is complementary to a region of a second gene associated with said pathological disorder or disease,
• wherein said pathological disorder is selected from the group consisting of abnormal appetite, hypertension, hypercholesterolemia, hyperlipidemia, erectile dysfunction, eczema, depression, anxiety, stress, inflammatory bowel syndrome, ulcerative colitis, Crohn's disease, renal stones, gall stones, constipation, migraine headache, seizure, multiple sclerosis, polymyositis, fibromyalgia, Parkinson's disease, ALS, chronic pain, pre-menstrual syndrome, chronic allergies, sinusitis, colds, trauma, carpal tunnel syndrome, chronic fatigue syndrome, rosacea, arthritis, psoriasis, prostatitis, inflammation, heartburn, infection, and poison ivy.