Delivery of agents such as cells to tissue

A nonimplantable system for delivering a fluid including cells to tissue of a patient, comprising:

• at least a first container for holding an injection fluid in which the cells are carried;
• a first powered drive in operative connection with the container, the first powered drive being operable to pressurize contents of the container;
• a control system in operative connection with the first powered drive and operative to control the first powered drive;
• a fluid path in fluid connection with the container, the fluid path including a patient interface adapted to deposit the cells within tissue of the patient;
• a sensor system comprising at least one cell sensor system to measure one or more properties indicative of the health of the cells and shear forces on the cells;
• and
• a communication system in connection with at least the control system and the sensor system, the sensor system being adapted to provide information to the control system, the control system being adapted to transmit a control signal to the first powered drive based at least in part on information provided to the control system.

A nonimplantable system for delivering a fluid including an agent to tissue of a patient, comprising:

• at least a first container for holding an injection fluid in which the agent is carried;
• a first powered drive in operative connection with the container, the first powered drive being operable to pressurize contents of the container;
• a control system in operative connection with the first powered drive and operative to control the first powered drive;
• a fluid path in fluid connection with the container, the fluid path including a patient interface adapted to deposit cells within tissue of the patient;
• a sensor system comprising at least one tissue sensor system to measure a property of the tissue at a delivery site and at least one fluid sensor system to measure a property of the fluid to be delivered;
• and
• a communication system in connection with at least the control system and the sensor system, the sensor system being adapted to provide information to the control system, the control system being adapted to transmit a control signal to the first powered drive based at least in part on information provided to the control system, wherein the sensor system provides a measurement indicative of at least shear forces on the cells.