Functionalised solid support for alpha-oxoaldehyde synthesis
AssigneesInstitut Pasteur de Lille, Centre National de la Recherche Scientifique (CNRS)
InventorsOleg Melnyk, Jean-Sebastien Fruchart, Line Bourel, Helene Gras-Masse
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Abstract
The invention relates to a functionalised solid support for the synthesis of compounds comprising at least one α-oxoaldehyde function, to a process for preparing it and to its applications, in particular for the preparation of a library of organic compounds, of a diagnostic reagent, of a microtitration plate and of a biochip, such as a DNA chip. The present invention also relates to a process for the synthesis of organic compounds comprising at least one α-oxoaldehyde function and to the α-oxoaldehyde peptides obtained using this process.
Claims10
A functionalized solid support according to formula I for the synthesis of compounds comprising at least one α-oxoaldehyde:
- wherein:
- S is a solid support having a surface that is well solvated in an aqueous or partially aqueous medium, wherein S is a polyacrylamide-polyethyleneglycol resin,
- m and n represent 1,
- B is a —(CH2)2—CO—NH— chain,
- Z is an amide group,
- A is a —CO—NH—(CH2)3— chain,
- P1 and P2 form together an isopropylidene protective group, protecting the hydroxyl functions in positions 1, 2;
- and;
- X′ is a —NH—(CH2)3—NH2 chain.
Dependencies are inferred from the claim text.