Lyophilized edible food incorporating a marker and methods of making
AssigneeAdvanced Breath Diagnostics, LLC
InventorsKerry C. Bush, Keith D. Evans, Stanley J. Konopka
Life of this patent
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Abstract
A standardized, lyophilized edible food containing a biologically safe stable marker for use in the measurement of gastric emptying by the quantification of marker excreted in the breath of the patient.
Claims43
A method of producing a lyopohilized product labeled with a marker comprising the sequential steps of:
- providing a marker;
- uniformly distributing a known amount of said marker throughout an edible food component, the edible food component comprising egg white and egg yolk;
- and
- lyophilizing the marker and the edible food component,
- wherein the marker is a 13C marker derived from a biomass, and wherein the marker binds to both the egg white and the egg yolk.
A method of producing a lyophilized product labeled with markers comprising the sequential steps of:
- providing a first marker and a second marker, the first marker comprising a 13C marker derived from a biomass and the second marker comprising a radioactive isotope;
- uniformly distributing a known amount of the first marker throughout an edible food component, the edible food component comprising egg white and egg yolk;
- lyophilizing the first marker and the edible food component;
- reconstituting the first marker and the edible food component;
- adding the second marker to the first marker and the edible food component, wherein the first marker binds to both the egg white and the egg yolk.
A method of producing a lyophilized product labeled with a marker comprising the sequential steps of:
- providing egg white and egg yolk;
- lyophilizing the egg white and egg yolk;
- reconstituting the egg white and egg yolk;
- adding a marker to the reconstituted egg white and egg yolk;
- and
- lyophilizing the marker and the reconstituted egg white and egg yolk, wherein the marker is a 13C marker derived from a biomass, and wherein the marker binds to both the egg white and the egg yolk.
A meal comprising:
- an edible food component;
- a known amount of a marker uniformly distributed throughout the edible food component, said marker being a 13C marker derived from a biomass and chosen so that when ingested by a mammal with the meal either the absorption or metabolism of the marker may be monitored and correlated to a physiological function of the mammal or a therapeutically effective amount of the marker delivered to the mammal;
- wherein the edible food component has been lyophilized and reconstituted before said known amount of marker is uniformly distributed throughout the edible food component, and wherein the edible food component and the marker have been lyophilized together after said known amount of marker is distributed throughout the edible food component, so that the edible food component has been lyophilized at least twice, wherein the edible food component comprises egg white and egg yolk, and wherein the marker is bound to both the egg white and egg yolk.
A meal comprising egg white and egg yolk, wherein the egg white and egg yolk are bound to a known amount of a 13C marker derived from a biomass, said 13C marker chosen so that when ingested by a mammal with the meal either the absorption or metabolism of the marker may be monitored and correlated to a physiological function of the mammal or a therapeutically effective amount of the marker delivered to the mammal, wherein the egg white and egg yolk have been lyophilized and reconstituted before the 13C marker is added to the egg white and egg yolk, and wherein the egg white and egg yolk and 13C marker have been lyophilized together after the marker is added to the egg white and egg yolk, so that the egg white and egg yolk have been lyophilized at least twice.
Dependencies are inferred from the claim text.