Method for augmentation of intraepithelial and systemic exposure of therapeutic agents having substrate activity for cytochrome P450 enzymes and membrane efflux systems following vaginal and oral cavity administration
AssigneeFemina Pharma Incorporated
InventorsGiovanni M. Pauletti, Donald C. Harrison, Kishorkumar J. Desai
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Abstract
A vaginal or buccal delivery of therapeutic agents having a substrate affinity for metabolic cytochrome P-450 enzymes and membrane efflux transporter systems. A method for augmentation of systemic exposure to the therapeutic agents having a substrate affinity for cytochrome P-450 enzymes and membrane efflux transporter systems, by delivering said agents to the systemic circulation through vaginal or buccal mucosa.
Claims22
An anti-viral or anti-cancer composition suitable for treatment of cancer and HIV/AIDS by providing a subject in need thereof with a mucosal composition administered vaginally or through an oral cavity, said composition comprising at least one anti-viral or one anti-cancer agent in an amount sufficient to provide a therapeutic effect in combination with 0.01 to 50% by weight of a non-ionizable glycol ether or with 0.001-10% by weight of a botanical bioavailability modulator, or a combination of both.
Dependencies are inferred from the claim text.