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US 8,173,831 B2Granted
Fatty acid acetylated salicylates and their uses
AssigneeCatabasis Pharmaceuticals, Inc.
InventorsJill C. Milne, Michael R. Jirousek, Jean E. Bemis, Jesse J. Smith
Life of this patent
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Abstract
The invention relates to Fatty Acid Acetylated Salicylate Derivatives; compositions comprising an effective amount of a Fatty Acid Acetylated Salicylate Derivative; and methods for treating or preventing an inflammatory disorder comprising the administration of an effective amount of a Fatty Acid Acetylated Salicylate Derivative.
Claims11
A compound of Formula I,
- or a pharmaceutically acceptable salt, enantiomer, or stereoisomer thereof, wherein:
- R1, R2, R3, and R4 are each independently selected from the group consisting of H, Cl, F, CN, —NH(C1-C3 alkyl), —N(C1-C3 alkyl)2, —NH(C(O)C1-C3 alkyl), —N(C(O)C1-C3 alkyl)2, —C(O)H, —C(O)C1-C3 alkyl, —C(O)OC1-C3 alkyl, —C(O)NH2, —C(O)NH(C1-C3 alkyl), —C(O)N(C1-C3 alkyl)2, —O—C1-C3 alkyl, —S(O)C1-C3 alkyl, and —S(O)2C1-C3 alkyl;
- W1 is NH and W2 is selected from null, O, or NH;
- - - - - - represents an optional bond that when present requires that Q is null;
- a and c are each independently H, CH3, —OCH3, —OCH2CH3, or C(O)OH;
- b is H, CH3, C(O)OH, or O—Z;
- d is H or C(O)OH;
- each n, o, p, and q is independently 0 or 1;
- each Z is H or
- with the proviso that there is at least one
- in the compound;
- each r is independently 2 or 3;
- each s is independently 5 or 6;
- each t is independently 0 or 1;
- Q is null, C(O)CH3, Z,
- e is H or any one of the side chains of the naturally occurring amino acids;
- W3 is null, —O—, or —N(R)—;
- R is H or C1-C3 alkyl;
- and
- T is H, C(O)CH3, or Z.
17 more elements
A pharmaceutical composition comprising a compound of Formula I:
- or a pharmaceutically acceptable salt, enantiomer, or stereoisomer thereof, wherein:
- R1, R2, R3, and R4 are each independently selected from the group consisting of H, Cl, F, CN, NH2, —NH(C1-C3 alkyl), —N(C1-C3 alkyl)2, —NH(C(O)C1-C3 alkyl), —N(C(O)C1-C3 alkyl)2, —C(O)H, —C(O)C1-C3 alkyl, —C(O)OC1-C3 alkyl, —C(O)NH2, —C(O)NH(C1-C3 alkyl), —C(O)N(C1-C3 alkyl)2, —C1-C3 alkyl, —O—C1-C3 alkyl, —S(O)C1-C3 alkyl, and —S(O)2C1-C3 alkyl;
- W1 is NH and W2 is selected from null, O, or NH;
- - - - - - represents an optional bond that when present requires that Q is null;
- a and c are each independently H, CH3, —OCH3, —OCH2CH3, or C(O)OH;
- b is H, CH3, C(O)OH, or O—Z;
- d is H or C(O)OH;
- each n, o, p, and q is independently 0 or 1;
- each Z is H or
- with the proviso that there is at least one
- in the compound;
- each r is independently 2 or 3;
- each s is independently 5 or 6;
- each t is independently 0 or 1;
- Q is null, C(O)CH3, Z,
- e is H or any one of the side chains of the naturally occurring amino acids;
- W3 is null, —O—, or —N(R)—;
- R is H or C1-C3 alkyl;
- and
- T is H, C(O)CH3, or Z;
- and a pharmaceutically acceptable carrier.
18 more elements
Dependencies are inferred from the claim text.