Attenuated recombinant newcastle disease virus and vaccine containing the same

A strain of Newcastle disease virus,

• comprising nucleotide sequences encoding NP, P, M, and L proteins of a low-pathogenic Newcastle disease virus AY845400;
• and nucleotide sequences encoding F and HN proteins of a high-pathogenic Newcastle disease virus KCTC 10919BP,
• wherein the F protein coding sequence comprised in the strain is characterized by substitution of the codon encoding the 115th amino acid of the F protein of the high-pathogenic Newcastle disease virus with any one selected from the group consisting of alanine codons consisting of GCA, GCC, GCG and GCU;
• aspartic acid codons consisting of GAC and GAU;
• phenylalanine codons consisting of UUC and UUU;
• isoleucine codons consisting of AUC and AUU;
• leucine codons consisting of UUA and UUG;
• serine codons consisting of UCA, UCC, UCG and UCU;
• threonine codons consisting of ACC and ACU;
• valine codons consisting of GUA, GUC, GUG and GUU;
• and tyrosine codons consisting of UAC and UAU,
• wherein the HN protein is a recombinant HN protein having the amino acid sequences of 570th and higher positions from the low-pathogenic Newcastle disease virus and the amino acid sequences from 1st to 569th positions from the high-pathogenic Newcastle disease virus.