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US 8,168,748 B2Granted
Peptide aptamers that bind to the rep proteins of ssDNA viruses
AssigneeNorth Carolina State University
InventorsLinda Hanley-Bowdoin, Luisa Lopez-Ochoa
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Abstract
Polypeptides and fusion proteins that bind to eukaryotic viruses, in particular, eukaryotic single-stranded DNA (ssDNA) viruses are provided. The polypeptides and fusion proteins bind to the replication initiation proteins (Rep) of ssDNA viruses and optionally inhibit viral replication and/or viral infection. The virus can be a plant pathogen or animal pathogen. Consensus sequences used to identify polypeptides that bind to eukaryotic viruses are also provided.
Claims20
A polypeptide comprising an amino acid sequence selected from the group consisting of:
- (a) the amino acid sequence of SEQ ID NO:25;
- (b) a fragment of the amino acid sequence of SEQ ID NO:25, wherein the fragment comprises one or more motifs selected from the group consisting of:
- (i) MLXXXXXG;
- and (ii) (G/S)CXLCXM, and wherein the fragment binds to a viral replication (Rep) protein;
- and
- (c) an amino acid sequence that is at least 95% similar to the amino acid sequence of (a) and binds to a viral replication (Rep) protein.
3 more elements
Dependencies are inferred from the claim text.