Compositions and methods for treatment of eye disorders
AssigneeSarcode Bioscience Inc.
InventorsThomas Gadek, John Burnier
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Abstract
The present invention provides compounds and methods for the treatment of LFA-1 mediated diseases. In particular, LFA-1 antagonists are described herein and these antagonists are used in the treatment of LFA-1 mediated diseases. One aspect of the invention provides for diagnosis of an LFA-1 mediated disease and administration of a LFA-1 antagonist, after the patient is diagnosed with a LFA-1 mediated disease. In some embodiments, the LFA-1 mediated diseases treated are dry eye disorders. Also provided herein are methods for identifying compounds which are LFA-1 antagonists.
Claims19
A method of treating dry eye disease in a subject in need thereof comprising administering to said subject an effective amount of an LFA-1 antagonist or its pharmaceutically acceptable salts or esters, wherein said LFA-1 antagonist is
- and wherein the subject does not have Sjogren's syndrome.
A method of treating dry eye disorder in a subject in need thereof comprising administering to an eye of said subject an effective amount of a pharmaceutical composition comprising an LFA-1 antagonist and/or its pharmaceutically acceptable salts or esters, wherein said LFA-1 antagonist is
- whereby said administration is effective in promoting tear secretion or mucin production in said eye in said subject, and wherein the subject does not have Sjogren's syndrome.
A method of treating dry eye disease in a subject comprising performing a dry eye diagnostic test on said subject;
- determining whether said subject suffers from a dry eye disease based on the results of said diagnostic step;
- and upon diagnosis of said dry eye disease, administering to said subject an effective amount of a lymphocyte function associated antigen-1 (LFA-1) antagonist or a pharmaceutically acceptable salt or ester thereof, wherein said LFA-1 antagonist is
- and wherein the subject does not have Sjogren's syndrome.
Dependencies are inferred from the claim text.