Prodrugs of GABA analogs, compositions and uses thereof
AssigneeXenoPort, Inc.
InventorsMark A. Gallop, Kenneth C. Cundy, Cindy X. Zhou, Fenmei Yao, Jia-Ning Xiang, Ian R. Ollman, Fayang G. Qiu
Life of this patent
Estimating the term…
Abstract
The present invention provides prodrugs of GABA analogs, pharmaceutical compositions of prodrugs of GABA analogs and methods for making prodrugs of GABA analogs. The present invention also provides methods for using prodrugs of GABA analogs and methods for using pharmaceutical compositions of prodrugs of GABA analogs for treating or preventing common diseases and/or disorders.
Claims9
A compound having the formula:
- a diastereomer thereof or a pharmaceutically acceptable salt thereof.
A compound having the formula:
- a diastereomer thereof or a pharmaceutically acceptable salt thereof.
A compound having the formula:
- a diastereomer thereof or a pharmaceutically acceptable salt thereof.
A pharmaceutical composition comprising a compound of formula:
- or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable vehicle, wherein:
- R7 and R14 are each hydrogen;
- R13 is selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl and sec-butyl;
- and
- R25 is selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, n-pentyl, isopentyl, sec-pentyl, neopentyl, and 1,1-diethoxyethyl.
A pharmaceutical composition comprising a compound having the formula:
- or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable vehicle.
An oral sustained release dosage form comprising a compound having the formula:
- or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable vehicle.
Dependencies are inferred from the claim text.