Polymeric sulfated surfactants for capillary electrophoresis (CE) and CE-mass spectrometry (CE-MS)
AssigneeGeorgia State University
InventorsShahab Ahmed Shamsi, Syed Asad Ali Rizvi
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Abstract
The present invention relates generally to methods for enantiomeric separation of complex chemical mixtures using micelles of surfactant molecules that have a sulfate or sulfonate head group, a chiral selector, a linker, and a hydrophobic tail. Also provided are micelle compositions with sulfate or sulfonated head groups, methods of manufacture, and applications thereof. In particular, the micelles of the present invention provide an efficient enantiomeric separation and detection techniques for use in capillary electrophoresis and capillary electrophoresis with mass spectrometry.
Claims7
A method for the detection and separation of enantiomers in a complex chemical mixture using capillary electrophoresis with mass spectrometry comprising contacting the complex chemical mixture with a micelle comprising at least two surfactant molecules of the formula:
- wherein R1 is a functionality group, R2 is a hydrophobic tail, R3 is a linker, R4 is a chiral selector, R5 is a head group comprising a sulfate or a sulfonate, and R6 is a counterion, wherein the functionality group is polymerized with at least one other surfactant molecule in the micelle;
- and
- separating enantiomers in the complex chemical mixture using capillary electrophoresis with mass spectrometry, wherein the detection and separation of enantiomers occurs at a pH from about 1.5 to about 5.5.
Dependencies are inferred from the claim text.