Aminodiazepines as toll-like receptor modulators

A compound of the Formula

• and tautomers and pharmaceutically acceptable salts thereof, wherein:
• Z is H, alkyl, alkenyl, alkynyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, OR6 or NR6R7, wherein said alkyl, alkenyl, alkynyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl are optionally substituted with one or more groups independently selected from alkyl, alkenyl, alkynyl, F, Cl, Br, I, CN, OR6, NR6R7, C(═O)R6, C(═O)OR6, OC(═O)R6, C(═O)NR6R7, (C1-C6 alkyl)amino, CH3OCH2O—, R6OC(═O)CH═CH2—, NR6SO2R7, SR6 and SO2R6;
• R1, R2, R3 and R4 are independently selected from H, alkyl, alkenyl, alkynyl, heteroalkyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, aryl and heteroaryl, wherein said alkyl, alkenyl, alkynyl, heteroalkyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, aryl, and heteroaryl are optionally substituted with one or more groups independently selected from alkyl, alkenyl, alkynyl, F, Cl, Br, I, CN, OR6, NR6R7, C(═O)R6, C(═O)OR6, OC(═O)R6, C(═O)NR6R7, (C1-C6 alkyl)amino, CH3OCH2O—, R6OC(═O)CH═CH2—, NR6SO2R7, SR6 and SO2R6,
• or R1 and R2 together with the atom to which they are attached form a saturated or partially unsaturated carbocyclic ring, wherein said carbocyclic ring is optionally substituted with one or more groups independently selected from alkyl, alkenyl, alkynyl, F, Cl, Br, I, CN, OR6, NR6R7, C(═O)R6, C(═O)OR6, OC(═O)R6, C(═O)NR6R7, (C1-C6 alkyl)amino, CH3OCH2O—, R6OC(═O)CH═CH2—, NR6SO2R7, SR6 and SO2R6,
• or R3 and R4 together are oxo;
• each R5 is independently selected from H, F, Cl, Br, I, OMe, CH3, CH2F, CHF2, CF3 and CF2CF3;
• R6 and R7 are independently selected from H or alkyl;
• and
• n is 0, 1, 2, 3 or 4.