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US 8,163,494 B2Granted
Method for assessing metastatic properties of breast cancer
AssigneeTechnion Research & Development Foundation Limited
InventorsGera Neufeld, Gal Akiri, Zahava Vadasz, Stela Gengrinovitch
Life of this patent
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Abstract
Methods and compositions suitable for modulating angiogenesis in a mammalian tissue are provided. Further provided are methods suitable for inhibiting metastasis and fibrosis in a mammalian tissue and for assessing the malignancy of colon cancer tumors.
Claims32
A method of determining that a breast tumor is metastatic, the method comprising:
- (a) obtaining a first sample of breast tumor tissue from a subject;
- (b) obtaining a second sample of breast tumor tissue, which is non-metastatic;
- and
- (c) determining that a tissue level and/or an activity level of a polypeptide set forth in SEQ ID NO:
- 2 is higher in the first breast tumor tissue sample than in the second breast tumor tissue sample;
- thereby determining that the tumor from which the first sample was derived is metastatic.
3 more elements
A method of determining that a breast tumor is metastatic or invasive, the method comprising:
- (a) obtaining a sample of breast tumor tissue from a subject;
- and
- (b) determining a tissue level and/or an activity level of a polypeptide set forth in SEQ ID NO:
- 2 in the breast tumor tissue sample;
- wherein a higher tissue level and/or activity level of said polypeptide, compared with that of a non-metastatic breast tumor tissue sample, indicates that the tumor from the subject is metastatic or invasive.
2 more elements
A method of determining that a breast tumor is metastatic, the method comprising:
- (a) assaying a tissue sample of the breast tumor for a tissue level and/or an activity level of a polypeptide set forth in SEQ ID NO:
- 2;
- and
- (b) determining that the tissue level and/or the activity level is higher in the breast tumor tissue sample than in a non-metastatic breast tumor tissue sample,
- thereby determining that the assayed tumor is metastatic.
2 more elements
Dependencies are inferred from the claim text.