Back to results
US 8,162,918 B2Granted
Gels with predetermined conductivity used in electroporation of tissue
AssigneeThe Regents of the University of California
InventorsAntoni Ivorra, Boris Rubinsky
Life of this patent
Estimating the term…
Abstract
Gel compositions with adjusted conductivity are disclosed which compositions are used for directing reversible electroporation and irreversible electroporation of cells and tissue. The gel compositions are also used in a similar manner in order to carry out thermotherapy on cells and tissues.
Claims10
A method of carrying out electroporation of tissue, comprising:
- inserting a gel into tissue in a patient wherein the gel has a predetermined conductivity relative to a surrounding tissue the gel being a colloidal disperson;
- applying current across the tissue in an amount so that cells of the tissue are subjected to electroporation;
- wherein the conductivity of the gel is sufficiently below that of the surrounding tissue such that when the current is applied to the tissue, substantially no current flows through the gel and the current is directed to a specific targeted area of the tissue to be electroporated.
A method of carrying out electroporation of tissue, comprising:
- inserting a gel into tissue in a patient by injection wherein the gel has a predetermined conductivity relative to tissue surrounding the gel;
- applying current across tissue in an amount so that cells of the tissue are subjected to electroporation;
- wherein the conductivity of the gel is predetermined by incorporating a known concentration of ions in the gel.
Dependencies are inferred from the claim text.