# US 8,162,873 B2 · Apparatus for administering a therapeutic agent into tissue > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 8,162,873 B2 - Document ID: US8162873B2 - Status: Granted - Kind: B2 - Application number: 12/430,740 - Filed: 2009-04-27 - Published: 2009-08-20 - Granted: 2012-04-24 - Earliest claimed: 2003-10-06 - Assignees: Ceramatec, Inc. - Inventors: Mario Muto; Kieran P. Murphy - Web page: https://patentgrep.com/patent/US8162873B2 ## CPC - A61M 5/28: Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle - A61B 17/3478: {Endoscopic needles, e.g. for infusion (biopsy needles A61B10/0233; catheters with injection needles A61M25/0067)} - A61K 33/00: Medicinal preparations containing inorganic active ingredients - A61K 33/40: Peroxides - A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca - A61P 19/02: for joint disorders, e.g. arthritis, arthrosis - A61P 25/04: Centrally acting analgesics, e.g. opioids - A61M 5/31511: {Piston or piston-rod constructions, e.g. connection of piston with piston-rod (A61M5/5066 takes precedence)} - A61M 25/065: {Guide needles} - A61M 2005/3114: {Filling or refilling} - A61M 2005/3128: {Incorporating one-way valves, e.g. pressure-relief or non-return valves} - A61M 2202/0208: Oxygen - A61M 2202/0216: Ozone - A61M 2210/1003: Spinal column - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract An apparatus for administering a therapeutic agent is provided. The apparatus, in an embodiment, includes an ozone generator connected to a scavenger and an ozone administrator via network of tubing and valves. When activated and the valves placed in the proper position, the ozone generator will fill the ozone administrator with ozone. The ozone generator can then be turned off and the valves moved so that the administrator can be disconnected from the remainder of the apparatus. The administrator is typically in the form of a syringe and needle. Once the syringe and needle is filled with ozone, the needle can be inserted into a tissue and the ozone expressed therefrom into the tissue. Various other apparatuses and methods are also contemplated. ## Claims ### Claim 1 An apparatus for administering a therapeutic agent comprising: a therapeutic agent generator; a scavenger in operable communication with the therapeutic agent generator; a therapeutic agent administrator in operable communication with the therapeutic agent generator and the scavenger, wherein said administrator comprises a syringe having a barrel and a plunger, wherein said syringe is detachable from said generator and said scavenger for portable administration of said therapeutic agent from said syringe; and a first valve positioned between the therapeutic agent generator and the therapeutic agent administrator, such that by operation of the first valve, the administrator can be filled and excess therapeutic agent can be captured by the scavenger. ### Claim 2 (depends on 1) The apparatus of claim 1, wherein said therapeutic agent comprises ozone. ### Claim 3 (depends on 2) The apparatus of claim 2, wherein said therapeutic agent comprises oxygen. ### Claim 4 (depends on 2) The apparatus of claim 2, wherein said ozone comprises gaseous medical ozone comprising a ratio of ozone (O3) to oxygen (O2). ### Claim 5 (depends on 4) The apparatus of claim 4, wherein said ratio of ozone to oxygen comprises about 1 μg/ml. ### Claim 6 (depends on 4) The apparatus of claim 4, wherein said ratio of ozone to oxygen comprises about 10 μg/ml. ### Claim 7 (depends on 4) The apparatus of claim 4, wherein said ratio of ozone to oxygen comprises about 20 μg/ml. ### Claim 8 (depends on 4) The apparatus of claim 4, wherein said ratio of ozone to oxygen comprises about 30 μg/ml. ### Claim 9 (depends on 4) The apparatus of claim 4, wherein said ratio of ozone to oxygen comprises about 40 μg/ml. ### Claim 10 (depends on 4) The apparatus of claim 4, wherein said ratio of ozone to oxygen comprises about 50 μg/ml. ### Claim 11 (depends on 4) The apparatus of claim 4, wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 1 μg/ml and about 90 μg/ml. ### Claim 12 (depends on 11) The apparatus of claim 11, wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 10 μg/ml and about 80 μg/ml. ### Claim 13 (depends on 12) The apparatus of claim 12, wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 20 μg/ml and about 70 μg/ml. ### Claim 14 (depends on 13) The apparatus of claim 13, wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 10 μg/ml and about 34 μg/ml. ### Claim 15 (depends on 14) The apparatus of claim 14, wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 27 μg/ml to about 28 μg/ml. ### Claim 16 (depends on 1) The apparatus of claim 1, wherein said generator comprises a medical ozone generator. ### Claim 17 (depends on 1) The apparatus of claim 1, further comprising a second valve, the first and second valves for controlling the flow of therapeutic agent between the therapeutic agent generator, the scavenger and the therapeutic agent administrator. ### Claim 18 (depends on 17) The apparatus of claim 17, wherein a combination of closing and opening each of the valves allows passage of therapeutic agent between the therapeutic agent generator and the therapeutic administrator without allowing therapeutic agent to access the scavenger. ### Claim 19 (depends on 17) The apparatus of claim 17, wherein a combination of closing and opening each of the valves allows passage of therapeutic agent between the therapeutic agent in the therapeutic administrator or between the therapeutic agent generator and the therapeutic administrator to access the scavenger. ### Claim 20 (depends on 1) The apparatus of claim 1, further comprising a second valve between the first valve and the therapeutic agent administrator, wherein said therapeutic agent administrator defines an internal space sufficient to maintain a discrete amount of said therapeutic agent, and wherein the second valve is configured to selectively maintain the discrete amount of the therapeutic agent within the barrel of the syringe upon detachment of the syringe from the generator and the scavenger, and to selectively deliver said therapeutic agent by placing the syringe in communication with a needle for the portable administration. ### Claim 21 An apparatus for administering a therapeutic agent comprising: a therapeutic agent generator; a scavenger in operable communication with said generator via a first valve for capturing said therapeutic agent; and a therapeutic agent administrator comprising a syringe having a barrel and a plunger, the barrel sufficient to maintain a discrete amount of said therapeutic agent, said administrator connectable to said generator via a second valve for selectively delivering said therapeutic agent, such that when said valves are in a first position said generator communicates with said administrator for filling said administrator with said agent and when said valves are in a second position said administrator retains said agent therein upon detachment from said generator and said scavenger captures any excess agent intermediate said administrator and said generator.