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US 8,158,374 B1Granted
Quantitative diagnostic methods using multiple parameters
AssigneeRidge Diagnostics, Inc.
InventorsYiwu He, Bo Pi, John Bilello
Life of this patent
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Abstract
Materials and Methods related to diagnosing a clinical condition in a subject, or determining the subject's predisposition to develop the clinical condition, using a multi-parameter system to measure a plurality of parameters and an algorithm to determine a disease score.
Claims5
A process for diagnosing a human subject as having or not having depression, comprising:
- (a) obtaining a measured level for each of brain-derived neurotrophic factor (BDNF), alpha-2-macroglobulin (A2M), and interleukin-13 (IL-13) in a blood or a urine sample from the subject;
- (b) comparing the measured levels with control levels of BDNF, A2M, and IL-13 in blood or urine samples, respectively, from normal human subjects who do not have depression;
- and
- (c) diagnosing the subject as having depression if (i) the measured levels of BDNF and IL-13 are lower than the control levels for BDNF and IL-13 and (ii) the measured level of A2M is higher than the control level for A2M, or diagnosing the subject as not having depression if (i) the measured levels of BDNF and IL-13 are not lower than the control levels for BDNF and IL-1 3 and (ii) the measured level of A2M is not higher than the control level for A2M.
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Dependencies are inferred from the claim text.